Given its non-invasive nature, there is increasing interest in the use of transcutaneous vagus nerve stimulation across basic, translational and clinical research. Contemporaneously, tVNS can be achieved by stimulating either the auricular branch or the cervical bundle of the vagus nerve, referred to as transcutaneous auricular vagus nerve stimulation and transcutaneous cervical VNS, respectively. In order to advance the field in a systematic manner, studies using these technologies need to adequately report sufficient methodological detail to enable comparison of results between (...) studies, replication of studies, as well as enhancing study participant safety. We systematically reviewed the existing tVNS literature to evaluate current reporting practices. Based on this review, and consensus among participating authors, we propose a set of minimal reporting items to guide future tVNS studies. The suggested items address specific technical aspects of the device and stimulation parameters. We also cover general recommendations including inclusion and exclusion criteria for participants, outcome parameters and the detailed reporting of side effects. Furthermore, we review strategies used to identify the optimal stimulation parameters for a given research setting and summarize ongoing developments in animal research with potential implications for the application of tVNS in humans. Finally, we discuss the potential of tVNS in future research as well as the associated challenges across several disciplines in research and clinical practice. (shrink)

Given its non-invasive nature, there is increasing interest in the use of transcutaneous vagus nerve stimulation across basic, translational and clinical research. Contemporaneously, tVNS can be achieved by stimulating either the auricular branch or the cervical bundle of the vagus nerve, referred to as transcutaneous auricular vagus nerve stimulation and transcutaneous cervical VNS, respectively. In order to advance the field in a systematic manner, studies using these technologies need to adequately report sufficient methodological detail to enable comparison of results between (...) studies, replication of studies, as well as enhancing study participant safety. We systematically reviewed the existing tVNS literature to evaluate current reporting practices. Based on this review, and consensus among participating authors, we propose a set of minimal reporting items to guide future tVNS studies. The suggested items address specific technical aspects of the device and stimulation parameters. We also cover general recommendations including inclusion and exclusion criteria for participants, outcome parameters and the detailed reporting of side effects. Furthermore, we review strategies used to identify the optimal stimulation parameters for a given research setting and summarize ongoing developments in animal research with potential implications for the application of tVNS in humans. Finally, we discuss the potential of tVNS in future research as well as the associated challenges across several disciplines in research and clinical practice. (shrink)

This volume focuses on the question of whether it is appropriate and inevitable that higher education systems are becoming so large and so diverse that the only realistic way they can be analysed is as aggregates of market-like transactions.

Book reviewed in this article: Practical Medical Ethics. By Alastair Campbell, Grant Gillett, and Gareth Jones. If I Were a Rich Man Could I Buy a Pancreas? and Other Essays on the Ethics of Health Care. By Arthur L. Caplan. Bloomington Ethics on Call: A Medical Ethicist Shows How to Take Charge of Life and Death Choices in Today's Health Care System. By Nancy Dubler and David Nimmons.

Recent magnetic resonance imaging and pathological studies have indicated that axonal loss is a major contributor to disease progression in multiple sclerosis. 1 H magnetic resonance spectroscopy, through measurement of N -acetyl aspartate, a neuronal marker, provides a unique tool to investigate this. Patients with primary progressive multiple sclerosis have few lesions on conventional MRI, suggesting that changes in normal appearing white matter, such as axonal loss, may be particularly relevant to disease progression in this group. To test this hypothesis (...) NAWM was studied with MRS, measuring the concentration of N -acetyl derived groups. Single-voxel MRS using a water-suppressed PRESS sequence was carried out in 24 patients with primary progressive multiple sclerosis and in 16 age-matched controls. Ratios of metabolite to creatine concentration were calculated in all subjects, and absolute concentrations were measured in 18 patients and all controls. NA/Cr was significantly lower in NAWM in patients than in controls, as was the absolute concentration of NA. There was no significant difference in the absolute concentration of creatine between the groups. This study supports the hypothesis that axonal loss occurs in NAWM in primary progressive multiple sclerosis and may well be a mechanism for disease progression in this group. (shrink)

In L. Frank Baum's story, Ozma of Oz, which is a sequel to Baum's much more famous story, The Wonderful Wizard of Oz, Dorothy and her companion come upon a wound-down mechanical man bearing a label on which are printed the following words: Smith and Tinker's Patent Double-Action, Extra-Responsive, Thought-Creating Perfect-Talking MECHANICAL MAN Fitted with our Special Clock-Work Attachment Thinks, Speaks, Acts, and Does Everything but Live As Dorothy and her companion are made to discover when they wind up this (...) man, he is indeed capable of doing all the things of which his label boasts—acting, speaking and even thinking. But as Tik-Tok himself insists, and no one in the story casts doubt on the matter, he is not alive. (shrink)

Extensive research has demonstrated that rs1360780, a common single nucleotide polymorphism within the FKBP5 gene, interacts with early-life stress in predicting psychopathology. Previous results suggest that carriers of the TT genotype of rs1360780 who were exposed to child abuse show differences in structure and functional activation of emotion-processing brain areas belonging to the salience network. Extending these findings on intermediate phenotypes of psychopathology, we examined if the interaction between rs1360780 and child abuse predicts resting-state functional connectivity (rsFC) between the amygdala (...) and other areas of the salience network. We analyzed data of young European adults from the general population (N = 774; mean age = 18.76 years) who took part in the IMAGEN study. In the absence of main effects of genotype and abuse, a significant interaction effect was observed for rsFC between the right centromedial amygdala and right posterior insula (p <.025, FWE-corrected), which was driven by stronger rsFC in TT allele carriers with a history of abuse. Our results suggest that the TT genotype of rs1360780 may render individuals with a history of abuse more vulnerable to functional changes in communication between brain areas processing emotions and bodily sensations, which could underlie or increase the risk for psychopathology. (shrink)

French translation of Gareth Evans' paper "Identity and Predication".

In lieu of an abstract, here is a brief excerpt of the content:Philosophical Adventures in the Lands of Oz and EvGareth B. Matthews (bio)Charles Dodgson, using the pen name “Lewis Carroll,” was the first author in English to write philosophical fantasy for children. In naming his first Alice book Alice’s Adventures in Wonderland,1 Lewis Carroll may have been inspired by the famous saying of Aristotle that philosophy begins in wonder. More exactly, what Aristotle said was this: “For it is owing (...) to their wonder (thaumazein) that people both now begin, and first began to philosophize (philosophein)” (Metaphysics I, 1982b12-13). Plato expresses a similar idea in his dialogue Theatetus: “This is an experience characteristic of philosophy,” Plato has Socrates say, “this wondering: this is where philosophy begins and nowhere else” (155d).A reader might suppose that the wonder Plato and Aristotle thought could stimulate us to do philosophy was a Kantian awe at “the starry heavens above me and the moral law within me.”2 But, in fact, the wonder Plato and Aristotle allude to is a surprised recognition that something we thought we understood perfectly well actually presents a challenging perplexity (aporia). So for both Plato and Aristotle, philosophy begins in the wonder at a philosophically interesting perplexity.3 And, indeed, Alice’s adventures in Wonderland are adventures in philosophical perplexity.The first American writer of philosophical fantasy for children was L. Frank Baum, author of The Wonderful Wizard of Oz4 and a number of other Oz books. For Baum philosophical fantasy took a rather different form from the fantasy of Lewis Carroll. This should hardly be surprising. After all, Carroll was a philosopher and an Oxford don whose specialty was logic. The hallmark of his fantasy is clever and thought- provoking [End Page 37] repartee, such as one might hope to hear at high table in an Oxford college. Consider this passage from chapter 7 (“A Mad Tea-Party”) of Alice in Wonderland:“Take some more tea,” the March Hare said to Alice, very earnestly.“I’ve had nothing yet,” Alice replied in an offended tone, “so I can’t take more.”“You mean you can’t take less,” said the Hatter: “it’s very easy to take more than nothing.”5As this passage helps us realize, “A has had more tea than B” is normally taken to imply that, although both A and B have had some tea, the amount that A has had is more than the amount that B has had. However, it can also be taken to mean simply that the amount A has had is more than the amount B has had, even where, in the case of B, that amount is zero. Or consider this exchange from chapter 6 (“Humpty-Dumpty”) of Through the Looking-Glass:“I don’t know what you mean by ‘glory,’” Alice said.Humpty Dumpty smiled contemptuously, “Of course you don’t—till I tell you.I meant ‘There’s a nice knock-down argument for you!’”“But ‘glory’ doesn’t mean ‘a nice knock-down argument,’” Alice objected.“When I use a word,” Humpty Dumpty said, in rather a scornful tone,“it means just what I choose it to mean—neither more nor less.”“The question is,” said Alice, “whether you can make words mean so many different things.”“The question is,” said Humpty Dumpty, “which is to be master—that’s all.”6This characteristically clever and amusing exchange forces readers to make a distinction between lexical meaning and speaker meaning. Of course the word “glory” does not mean “there’s a nice knock-down argument for you,” but what a speaker might mean to communicate by using the word “glory” is another issue. Moreover, the relationship between lexical meaning and speaker meaning is a very interesting issue in linguistics and the philosophy of language.Nothing like this clever repartee is to be found in the Oz books. Nor should that fact be very surprising. Frank Baum never took a philosophy course; he never even went to college. He was a theater producer and journalist. Yet, despite this lack of academic background, perhaps the most striking feature7 of Baum’s writing—something almost universally ignored in the scholarly literature on Baum... (shrink)

To think about how to anchor abstract symbols to objects in the world is to become part of a tradition in philosophy with a long history, and an especially rich recent past. It is to ask, with Wittgenstein, “What makes my thought about him, a thought about him?” and thus it is to wonder not just about the nature of referring expressions or singular terms, but about the nature of referring beings. With this in mind I hereby endeavor—briefly, incompletely, but (...) hopefully still usefully—to introduce what in my judgment is the single best philosophical starting-point for those interested in understanding the referential connections between symbols and the world, and the cognitive, epistemic, and linguistic capacities which support them: The Varieties of Reference by Gareth Evans.1 It is worthwhile first of all to note, as the title indicates, that it is the varieties of reference that are of interest. It is Evans’ contention that no single theory can account for our various use of singular terms; although the different kinds of reference share certain features, and rely on related cognitive, linguistic and epistemic capacities, it appears that, rather than being a class defined by necessary and sufficient criteria for membership, they form a family of abilities, united, like a thread, by its overlapping fibers. Evans does not defend this claim so much as display it in his account. Much of the underlying variety in reference can be brought out by considering the guiding principle of the work as a whole, which Evans.. (shrink)

Gareth Matthews suggests that we can better understand the nature of philosophical inquiry if we recognize the central role played by perplexity. The seminal representation of philosophical perplexity is in Plato's dialogues; Matthews examines the intriguing shifts in Plato's attitude to perplexity and suggests that these may represent a course of philosophical development that philosophers follow even today.

Dialogues generated over a year of weekly meetings with 8 children at a school in Edinburgh. The author and the children attempted to craft stories reflecting philosophical problems.

Invited media scholars and journalists examine the general issue of nuclear waste, risk and the sicentific promises that were made, but not kept, about safe disposal. The mass media uncovered and reported on nuclear waste problems at Rocky Flats in Colorado and Hanford in Washington. Two environmental journalists review efforts to expose problems at these sites, how secrecy hampered reporting, and the effects of media coverage on nearby residents. An environmental communications scholar evaluates media coverage, the role of the U.S. (...) Department of Energy, and the impact of secrecy on public risk perceptions and attitudes toward government nuclear waste policies. (shrink)

The essential overview of the key philosophical ideas and controversies that have shaped the world of science.

We consider the question of when an expansion of a first-order topological structure has the property that every open set definable in the expansion is definable in the original structure. This question has been investigated by Dolich, Miller and Steinhorn in the setting of ordered structures as part of their work on the property of having o-minimal open core. We answer the question in a fairly general setting and provide conditions which in practice are often easy to check. We give (...) a further characterisation in the special case of an expansion by a generic predicate. (shrink)

We report on an interview-based study of decision-making capacity in two classes of patients suffering from depression. Developing a method of second-person hermeneutic phenomenology, we articulate the distinctive combination of temporal agility and temporal inability characteristic of the experience of severely depressed patients. We argue that a cluster of decision-specific temporal abilities is a critical element of decision-making capacity, and we show that loss of these abilities is a risk factor distinguishing severely depressed patients from mildly/moderately depressed patients. We explore (...) the legal and clinical consequences of this result. (shrink)

This paper defends an orthodox model of the linguistic intuitions which form a central source of evidence for generative grammars. According to this orthodox conception, linguistic intuitions are the upshot of a system of grammatical competence as it interacts with performance systems for perceiving and articulating language. So conceived, probing speakers’ linguistic intuitions allows us to investigate the competence–performance distinction empirically, so as to determine the grammars that speakers are competent in. This model has been attacked by Michael Devitt in (...) his recent book and a series of papers. In its place, Devitt advances a model of linguistic intuitions whereby they are speakers’ theory-laden judgements about the properties of languages. In this paper, I try to make clear the rationale behind the orthodox model and the inadequacies of Devitt's model. (shrink)

Adult preconceptions about the mental life of children tend to discourage a child’s philosophical bent. By exposing the underpinnings of adult views of childhood, Matthews clears the way for recognizing the philosophy of childhood as a legitimate field of inquiry and conducts us through influential models for understanding what it is to be a child.

With the waves of reform occurring in mental health legislation in England and other jurisdictions, mental capacity is set to become a key medico-legal concept. The concept is central to the law of informed consent and is closely aligned to the philosophical concept of autonomy. It is also closely related to mental disorder. This paper explores the interdisciplinary terrain where mental capacity is located. Our aim is to identify core dilemmas and to suggest pathways for future interdisciplinary research. The terrain (...) can be separated into three types of discussion: philosophical, legal and psychiatric. Each discussion approaches mental capacity and judgmental autonomy from a different perspective yet each discussion struggles over two key dilemmas: whether mental capacity and autonomy is/should be a moral or a psychological notion and whether rationality is the key constitutive factor. We suggest that further theoretical work will have to be interdisciplinary and that this work offers an opportunity for the law to enrich its interpretation of mental capacity, for psychiatry to clarify the normative elements latent in its concepts and for philosophy to advance understanding of autonomy through the study of decisional dysfunction. The new pressures on medical and legal practice to be more explicit about mental capacity make this work a priority. (shrink)

Corporate social responsibility (CSR) is widely viewed as an important feature of contemporary business. It is characterized by the notion that organizations ought to voluntarily recognize and, where possible, practically mitigate the social impacts of its business activities, and that doing so allows organizations to meet the expectations of affected stakeholders. However, CSR initiatives are almost universally tethered to the idea that corporations exist to serve their own performance objectives, and that these will ultimately take precedence over wider macro-social considerations. (...) The present paper proposes that this conception of CSR mirrors the underlying neurological tension between the domains of analytic reasoning and empathic or socioemotional reasoning, and the neural correlates of each. Using the opposing domains hypothesis, it is proposed that CSR, as it is currently conceived of and practiced, is antithetical to social and ethical reasoning at the level of the brain, can increase the scope for dehumanization, and demands calling the ethical dimensions of CSR into question. (shrink)

'Words of Wisdom' is an anthology of history's most memorable, uplifting or thought-provoking quotations from the greatest philosophers who have ever lived. Each of the 360 quotations is accompanied by a brief essay that tells the story of the speaker or explains the circumstances that gave rise to the quotation.

Theoria, EarlyView. -/- In his recent book Thin Objects, Øystein Linnebo (2018) argues for the existence of a hierarchy of abstract objects, sufficient to model ZFC, via a novel and highly interesting argument that relies on a process called dynamic abstraction. This paper presents a way for a nominalist, someone opposed to the existence of abstract objects, to avoid Linnebo's conclusion by rejecting his claim that certain abstraction principles are sufficient for reference (RBA). Section 1 of the paper explains Linnebo's (...) argument for RBA. It offers a reading of Linnebo's work upon which he has two arguments for RBA: one deductive and one abductive, and argues that whilst the deductive argument is unsound the abductive one is prima facie plausible. The nominalist must therefore find a way to respond to the abductive argument. Section 2 outlines just such a response, by offering an alternative explanation of the cases Linnebo wishes to argue from. Most interestingly, it shows that abstraction in Linnebo's most difficult case (the “reference to ordinary bodies” case) can be achieved using mereological means, rather than relying on RBA. (shrink)

In a recent paper, Jc Beall has employed what he calls ‘shriek rules’ in a putative solution to the long-standing ‘just false’ problem for glut theory. The purpose of this paper is twofold: firstly, I distinguish the ‘just false’ problem from another problem, with which it is often conflated, which I will call the ‘exclusion problem’. Secondly, I argue that shriek rules do not help glut theorists with either problem.

SUMMARYThe nineteenth-century Orientalist and ethnologist, John Crawfurd, publicly rejected Charles Darwin’s theory of evolution in 1868. Crawfurd was a leading advocate of polygenesis but also a supporter of racial equality. In 1820 he published his History of the Indian Archipelago, where he advocated granting household suffrage to all races in the British colonies. After finishing a career in the East India Company in 1828 he became the foremost expert on South-East Asia in Britain. Crawfurd became a regular writer on ethnology (...) and Asian affairs for the Examiner newspaper and in the 1860s he was President of the Ethnological Society of London. Accounts of nineteenth-century anthropology in Britain characterise debate around race as falling into two camps: advocates of monogenesis and advocates of polygenesis. In the United States of America, advocates of polygenesis were often associated with advocates of slavery and racial inequality. Recent research has demonstrated that Charles Darwin’s hatred of slavery drove him to write Origin of the Species to demonstrate the unity of the human species and reject the polygenesis position. This paper explores Crawfurd’s ideas and demonstrates that a belief in polygenesis in the nineteenth century did not necessarily equate with a belief in racial inequality. (shrink)

In this paper, I present an analysis of those aspects of Karl Polanyi's social and political thought that relate to environmentalism and 'green' politics today. I discuss whether or not he prefigured the degrowth movement, before focusing on his understanding of the New Deal (1933-1939). At the time of writing, the prospect appears likely of a return, at a global scale, of economic slump, mass unemployment and ecological crisis, the background conditions to which Franklin D. Roosevelt's New Deal was responding (...) on the national scale. The paper concludes by drawing lessons from this comparison for possible Green New Deals. (shrink)

In ‘Thinking Beyond the Lockdown’, Panagiotis Sotiris argues that lockdowns are repressive and should be opposed. In this response I take issue with his analysis. He posits the existence of a ‘lockdown strategy’ which has little relation to reality. He identifies lockdowns with neoliberalism, flirts with the Great Barrington project, and calls for anti-lockdown resistance – without so much as a glance at the right-wing libertarian camps that are also staked out on this terrain. On these points, and in respect (...) of his interpretation of Foucault, I offer a rebuttal. (shrink)

Generalising work of Berenstein, Dolich and Onshuus (Preprint 145 on MODNET Preprint server, 2008) and Günaydın and Hieronymi (Preprint 146 on MODNET Preprint server, 2010), we give sufficient conditions for a theory TP to inherit N I P from T, where TP is an expansion of the theory T by a unary predicate P. We apply our result to theories, studied by Belegradek and Zilber (J. Lond. Math. Soc. 78:563–579, 2008), of the real field with a subgroup of the unit (...) circle. (shrink)